Cholinergic activity and levodopa-induced dyskinesia: a multitracer molecular imaging study
نویسندگان
چکیده
منابع مشابه
Cholinergic activity and levodopa‐induced dyskinesia: a multitracer molecular imaging study
OBJECTIVE To investigate the association between levodopa-induced dyskinesias and striatal cholinergic activity in patients with Parkinson's disease. METHODS This study included 13 Parkinson's disease patients with peak-of-dose levodopa-induced dyskinesias, 12 nondyskinetic patients, and 12 healthy controls. Participants underwent 5-[123I]iodo-3-[2(S)-2-azetidinylmethoxy]pyridine single-photo...
متن کاملDiabetes Increases the Incidence of Levodopa-Induced Dyskinesia in Parkinson’s Disease; A Case-Control Study
Background and Objective: Dyskinesia is a debilitating complication of Parkinsonchr('39')s disease (PD), which appears due to some known risk factors. The effect of diabetes and high plasma glucose on the manifestation of dyskinesia has been evaluated in just a few previous reports. The current study aimed to assess the mentioned correlation. Materials and Methods: In this case-control study, ...
متن کاملLevodopa-induced dyskinesia and thalamotomy.
Levodopa-induced dyskinesia of the limbs in thirteen cases of Parkinsonism, which was choreic, ballistic or dystonic in type, was alleviated almost completely by stereotaxic surgery using a microelectrode technique for the ventralis oralis anterior and posterior nuclei of the thalamus, but much less by the ventralis intermedius nucleus. Control of levodopa-induced dyskinesias by thalamic lesion...
متن کاملLevodopa-induced dyskinesia and striatal signaling pathways.
P arkinson’s disease (PD) is the most common movement disorder, affecting 2% of individuals over age 60 (1). The cardinal clinical features of PD are resting tremor, rigidity, bradykinesia, and postural instability, which are often accompanied by autonomic, cognitive, and emotional disturbances. The neuropathological hallmark of PD is the degeneration of dopaminergic neurons in the substantia n...
متن کاملLevodopa-Induced Dyskinesia: Medical and Surgical Management
Although levodopa therapy remains the most effective symptomatic treatment for PD, its usefulness may be limited by these motor complications, which result in deterioration in quality of life. Levodopa-induced dyskinesia (LID) is characterized by a variety of hyperkinetic movements. Although chorea and dystonia are the most common manifestations of LID, stereotypies, tics, myoclonus, or ballism...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Annals of Clinical and Translational Neurology
سال: 2017
ISSN: 2328-9503
DOI: 10.1002/acn3.438